Educational Aspects of Computer Reconstruction of Gene Networks Based on Online Bioinformatics Tools

Orlov Y.L., Turkina V.A., Karpyn A.B., Anashkina A.A., Lebedev G.S.

The Digital Health Institute, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia e-mail:

The report will consider the issues of computer reconstruction of gene networks - complexes of interacting macromolecules - according to the list of genes associated with a particular disease, or a complex disorder based on publicly available online bioinformatics tools - STRING-DB, GeneMANIA, Cytoscape applications. Examples of computer construction and visualization of gene networks of oncological diseases - glioma, breast cancer, as well as complex mental disorders such as Parkinson's disease, schizophrenia, which were published in co-authorship with students in Russian and international journals in 2021-2022 are presented. The use of only online bioinformatics tools is educationally oriented. It is focused on the students, both in mathematics and in natural sciences and medical disciplines, who do not have enough skills in computer science, programming, and writing their own code. Automatic construction of lists of genes associated with a disease using open databases (OMIM,, computer reconstruction of gene networks, calculations of enrichment statistics for categories of gene ontologies were successfully mastered by students and presented in a series of theses. Assessment of students' skills is given on the basis of teaching at NSU, FEFU, Peoples' Friendship University of Russia, I.M. Sechenov First Moscow State Medical University of the Russian Ministry of Health. The project is implemented by the winner of Master's Program Faculty Grant Competition of the Vladimir Potanin Fellowship Program.


© 2004 Designed by Lyceum of Informational Technologies №1533