Conference publications


XXIV conference

The dynamics of the open state of the DNA molecule under the influence of external periodic influences

Balashov V.N., Yakushevich L.V.1, Zakiryanov F.K.

Bashkir State University

1Institute of Cell Biophysics

1 pp. (accepted)

Constant growth in the number of devices in the technology and consumer spheres of human activity makes it relevant to the question of the effect of fixed and variable physical fields on living organisms. In this paper we consider the problem associated with this direction: we will examine the impact of direct and alternating fields on the movement of "open state" of the DNA molecule. [1]

The DNA molecule can be considered as a multi-component physical si-tem, consisting of a large number in a certain way are located in the pro-space atomic groups that form a double helix, and connected with each other a variety of strong and weak ties. This system is static and has no internal mobility due to the influence of temperature, the collision with the molecules of the solution, protein interaction, etc.

In our work, we have considered the model effectively takes into account the heterogeneity of the grounds. In the model it is assumed that only the angular oscillation around the bases of the sugar-phosphate chains contribute to the disclosure of base pairs and unwinding the double helix, i.e. in the education of the "open state" process.

For the mathematical description of the rotational dynamics of DNA often use a simple model Inglendera based on the sine-Gordon equation. One of his solutions in the form of a kink is a mathematical way open state of the DNA mole--ly.

Using analytical methods and techniques of computer modeling, we obtained and analyzed data on the behavior of the main characteristics of the movement of "open state" for pTTQ18 plasmid. Found time dependence bridge speed, position, size and energy of the kink at different values ​​of parameters-ditch external torsion moment. It is shown that changing these settings, on and off the external action, can adjust the speed and direction of movement of the kink.

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