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Conference publicationsAbstractsXX conferenceSystem to store DNA electrostatic potential profilesInstitute of Cell Biophysics RAS, Russia, 142290, Pushchino, Institutskaya str.3, phone: (4967)739319, E-mail: evgenia.teml@gmail.com 1 pp. (accepted)Sequencing of a large number of bacterial complete genomes and development of high-throughput experimental techniques cause the rapid growth in transcription factor binding sites data and information about their mutual influence. The analysis of the effect of DNA physical properties, such as the electrostatic potential, on the rate of transcription initiation is not possible without database infrastructure for biological and physical data. Database to store, search and retrieve DNA electrostatic potential profiles has been developed and its use for analysis of { E. coli} promoters has been demonstrated. Unique feature of the database is in its ability to handle whole profile as single internal object type in a way similar to integers or character strings [1], [2]. To demonstrate utility of such database it was populated with data of 1227 known promoters, their nucleotide sequence, profile of electrostatic potential [3], transcription factor binding sites. Each promoter is also connected to all genes, whose transcription is controlled by that promoter. Database available at http://promodel.icb.psn.ru/eldna. Work was supported by RFBR №11-04-01436-а.
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