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PresentationsEstablishment Of Factors Of Comorbid Course Of Diseases Of The Transition Period Of Dairy CowsFSBEI HE Chuvash State Agrarian University, Russia, 428003, Cheboksary, st. K. Marksa, 29, for.anton_step@mail.ru Among the cattle diseases that cause the greatest economic damage, special attention should be paid to pathologies of the prenatal and postnatal periods, namely: mastitis, hoof lesions, abomasal displacement, dystocia, metritis, hypocalcemia, placental retention and ketosis [2]. In production conditions, veterinary specialists are forced to perform emergency therapeutic manipulations in relation to sick animals, without determining the etiological factors, blindly using antibacterial agents. The main gateway for such concomitant diseases is considered to be the exogenous route [1], however, given modern technologies and measures to protect animal health, external factors are losing their significance and a violation of the rumen microbiota of ruminants comes to the leading position, which can damage the barrier of the mucous membrane of the forestomachs and intestines, and the bacteria themselves and their metabolites can migrate to distal extraintestinal organs. The purpose of this scientific study is to isolate the population of microorganisms from biological samples of cows with comorbid course of diseases of the transition period, to develop mathematical models describing the growth and reproduction of populations in the conditions of the animal's body taking into account the determining factors and to develop complex measures to combat them based on the prevention of endogenous circulation of pathogenic and opportunistic bacteria. The main mathematical models are multifactorial models studying the mechanisms of population growth, as well as molecular dynamics models of the interaction of individual proteins with bactericidal action, such as lactoferrin, with the bacterial cell wall. Thus, when determining the pathogenic factors of diseases of cows in the transition period, we are inclined to the concept of the "rumen-enterogenic pathogenetic factor" and believe that the indirect pathway "rumen/intestine - mammary gland, endometrium, hooves" is an important pathological mechanism in the development of diseases of the transition period of cows.
References. 1. LeBlanc S. J. Postpartum reproductive disease and fertility in dairy cows // Animal, 17, 2023, P. 100781. 2. Rasmussen P., Herman W. B., Prince P. O. Global losses due to dairy cattle diseases: A comorbidity-adjusted economic analysis // Journal of Dairy Science, 9, No. 107, 2024, P. 6945 – 69 70
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